منابع مشابه
Proteolytic autodigestion
www.landesbioscience.com Cell Cycle 3457 Disease modeling using induced pluripotent stem cells (iPSCs) and human embryonic stem cells (hESCs) promises to reveal underlying pathophysiology, especially for genetic diseases that manifest pathologic tissue development, or in cases where disease tissues are largely destroyed by disease at the time of diagnosis. Shwachman–Diamond syndrome (SDS), a ra...
متن کاملAutodigestion: Proteolytic Degradation and Multiple Organ Failure in Shock.
There is currently no effective treatment for multiorgan failure following shock other than supportive care. A better understanding of the pathogenesis of these sequelae to shock is required. The intestine plays a central role in multiorgan failure. It was previously suggested that bacteria and their toxins are responsible for the organ failure seen in circulatory shock, but clinical trials in ...
متن کاملThe autodigestion hypothesis: Proteolytic receptor cleavage in rheological and cardiovascular cell dysfunction1
Transformation of circulating leukocytes from a dormant into an activated state with changing rheological properties leads to a major shift of their behavior in the microcirculation. Low levels of pseudopod formation or expression of adhesion molecules facilitate relatively free passage through microvessels while activated leukocytes with pseudopods and enhanced levels of adhesion membrane prot...
متن کاملAutodigestion in crude extracts of soybean leaves and isolated chloroplasts as a measure of proteolytic activity.
Two methods of measuring protein breakdown resulting from self-digestion during incubation in extracts of soybean leaves were examined. The release of free alpha-amino-nitrogen was measured with ninhydrin, and the disappearance of the large subunit of ribulose bisphosphate carboxylase (RuBPcase) was followed with sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Rates of protein breakd...
متن کاملMutant LexA proteins with specific defects in autodigestion.
In self-processing biochemical reactions, a protein or RNA molecule specifically modifies its own structure. Many such reactions are regulated in response to the needs of the cell by an interaction with another effector molecule. In the system we study here, specific cleavage of the Escherichia coli LexA repressor, LexA cleaves itself in vitro at a slow rate, but in vivo cleavage requires inter...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2013
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.26698